Moersch-Woltman Syndrome - An Uncommon Conundrum

Authors

DOI:

https://doi.org/10.5195/ijms.2024.2472

Keywords:

Anti-GAD Antibodies, Moersch-Woltman Syndrome, Stiff-Person Syndrome, Treatment

Abstract

Recently, this Journal published an interesting case study about the Moersch-Woltman syndrome that affected a middle-aged female, who had not an early diagnosis of this uncommon condition and was longtime submitted to polypharmacy without any improvement of the relentless course of this disease. The authors commented on the importance of a high index of suspicion to get an early correct diagnosis and prompt effective management that is indispensable to result in the best outcomes. The additional short comments on novel literature data aim to emphasize the exemplifying role of reported cases, mainly by enhancing the awareness of non-specialists and primary healthcare workers.

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References

Pitliya A. A Rare Case Report of Neurological Condition: Moersch-Woltman Syndrome with Positive Anti-GAD Antibodies. Int J Med Stud. 2023;11(3):233-6.

Chia NH, McKeon A, Dalakas MC, Flanagan EP, Bower JH, Klassen BT, et al. Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria. Ann Clin Transl Neurol. 2023;10(7):1083-94.

Kamaleshwaran KK, Ramkumar E, Senthilkumar E. F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Muscle Uptake in Antiglutamic Acid Decarboxylase Antibody-positive Stiff-Person Syndrome. Indian J Nucl Med. 2023;38(2):162-4.

Matsui N, Tanaka K, Ishida M, Yamamoto Y, Matsubara Y, Saika R, et al. Prevalence, Clinical Profiles, and Prognosis of Stiff-Person Syndrome in a Japanese Nationwide Survey. Neurol Neuroimmunol Neuroinflamm. 2023;10(6):e200165.

Perri M, Pellegrini D, Uribe Roca C, Gonzalez F, Buero A, Chimondeguy D, et al. Síndrome de la persona rígida asociado a timoma. Medicina (B Aires). 2023;83(4):626-30.

This image is an artistic representation of Moersch-Woltman Syndrome, also known as stiff-person syndrome. It features the profile of a human figure with anatomical details of muscles, nerves, and connective tissue emphasized. Surrounding the figure are scientific elements, including a DNA helix, molecular structures like GAD65 (associated with the syndrome), and abstract cellular imagery. The design blends medical science and artistry to illustrate the biological underpinnings of the condition in a visually striking manner.

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Published

2024-10-03 — Updated on 2024-12-17

How to Cite

Dos Santos, V. M., C. Modesto, L., & C. Modesto, J. (2024). Moersch-Woltman Syndrome - An Uncommon Conundrum . International Journal of Medical Students, 12(4), 489–490. https://doi.org/10.5195/ijms.2024.2472

Issue

Vol. 12 No. 4 (2024)

Section

Letter to the Editor

Categories

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Copyright (c) 2024 Vitorino M. Dos Santos, Laura Campos Modesto, Julia Campos Modesto

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