Rectus Sheath Hematoma Following Subcutaneous Enoxaparin Application: A Case Report
DOI:
https://doi.org/10.5195/ijms.2023.2289Keywords:
Rectus Abdominis, Hematoma, Enoxaparin, Case Report, AnticoagulantsAbstract
BACKGROUND: Thromboprophylaxis for prevention of venous thromboembolism has significantly decreased morbidity and mortality for post-operative patients over the previous decades. However, patients on anticoagulants are at risk for several major bleeding events, such as rectus sheath hematoma. Rectus sheath hematoma is an uncommon, potentially life-threatening complication that can be difficult to diagnose and easily confused with other abdominal pathologies. It most commonly occurs in patients on current prophylactic or therapeutic anticoagulants and can be spontaneous or provoked. Inadvertent damage to the rectus abdominis muscle or epigastric arteries during subcutaneous enoxaparin injection in the abdomen has been identified as a rare cause of this complication.
THE CASE: A 68-year-old hospitalized female presented acute abdominal pain in the right lumbar and iliac region accompanied by hypotension and tachycardia eight days after uncomplicated total knee arthroplasty. She was found to have severe anemia on laboratory exam and a right rectus sheath hematoma on abdominal CT scan with a volume of 300cc. After the patient was stabilized via fluid resuscitation and blood transfusion, the hematoma was surgically drained. The surgeons involved noted possible inadvertent puncture of the right inferior epigastric artery during one of the patient’s bi-daily subcutaneous enoxaparin injections.
CONCLUSION: This case report emphasizes the importance of recognizing rectus sheath hematoma as a potential complication of subcutaneous enoxaparin injection and the knowledge of its risk-factors and clinical presentation to make an early diagnosis and give adequate treatment.
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References
Waxman MJ, Griffin D, Sercy E, Bar-Or D. Compliance with American College of Chest Physicians (ACCP) recommendations for thromboembolic prophylaxis in the intensive care unit: a level I trauma center experience. Patient Safety in Surgery. 2021;15(1):13.
Chan NC, Bhandari M. Thromboprophylaxis After Hip or Knee Arthroplasty. JAMA. 2022;328(8):712-713.
Agarwal S, Lamani YP, Goudar BV, Kalburgi EB, Bhavi BK. Rectus Sheath Haematoma Secondary to Enoxaparin Injection- A Rare Case Report. J Clin Diagn Res. 2017;11(3):11-12.
Kapan S, Turhan AN, Alis H, Kalayci MU, Hatipoglu S, Yigitbas H, et al. Rectus sheath hematoma: three case reports. Journal of Medical Case Reports. 2008;2(1):22.
Sharayah AM, Zaigham S, Hajjaj N, Maniar M. A complication of enoxaparin injection. Cleveland Clinic Journal of Medicine. 2019;86(10):648-649.
Dutta S, Sanjay P, Jones ML. Diagnosis and treatment of giant lateral abdominal wall haematoma after blunt trauma: a case report. Cases Journal. 2019;2(1):9358.
Hatjipetrou A, Anyfantakis D, Kastanakis M. Rectus sheath hematoma: A review of the literature. International Journal of Surgery. 2015;13:267-271.
Mendes D, Penedones A, Martins M, Cavadas S, Alves C, Batel-Marques F. Rectus sheath hematoma in patients receiving subcutaneous enoxaparin: A case series of five patients. Clin Case Rep. 2020;8(12):3432-3439.
Allen M, Sevensma KE. Rectus Sheath Hematoma. StatPearls Publishing. 2023;
Bello G, Blanco P. Giant rectus sheath hematoma. The Ultrasound Journal. 2019;11(1):13.
Liao ED, Puckett Y. A Proposed Algorithm on the Modern Management of Rectus Sheath Hematoma: A Literature Review. Cureus. 2021;13(11):e20008.stat
Chung KT. Intra-Abdominal Hematoma following Enoxaparin Injection. Clinical Medicine Insights: Case Reports 2016;9:CCRep.S17881.
Kayrak M, Bacaksiz A, Yazici M. Is enoxaparin injection from the abdominal wall safe in elderly people?: a fatal case of rectus sheath hematoma. Can Fam Physician 2008;54(9):1246-1248.
Anderson DR, Dunbar M, Murnaghan J, Kahn SR. Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty. New England Journal of Medicine. 2018;378(8):699-707.
Sidhu VS, Kelly TL, Pratt N, Graves SE, Buchbinder R, Adie S, et al. Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial. JAMA. 2022;328(8): 719-727.
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