Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps

Authors

  • Adnan Khan Rehman Medical College, Peshawar, Pakistan.
  • Raza Jamali Rehman Medical College, Peshawar, Pakistan.
  • Muneeb Jan Rehman Medical College, Peshawar, Pakistan.
  • Maria Tasneem Postgraduate trainee, Histopathology Department, Rehman Medical Institute, Peshawar, Pakistan.

DOI:

https://doi.org/10.5195/ijms.2014.78

Keywords:

Breast Neoplasms, biopsy, Cytological Techniques, Fine-Needle Biopsy

Abstract

Background: A large number of patients have been suffer from breast cancer worldwide and this trend is increasing. It is difficult to determine whether a lump is benign or malignant from clinical assessment; thus, the need for micropic and tissue analysis arises. Methods: This comparative retrospective cross sectional study was conducted in the Department of Pathology, Rehman Medical Institute, Peshawar, Pakistan from January 2006 to March 2013, to determine the value of fine needle aspiration cytology (FNAC) in the diagnosis of breast lump and to compare the result of FNAC with histological diagnosis to assess its accuracy. Results: Seventy-four  cases with breast lumps were presented for FNAC. Of these, 32.4% were reported as a C2 lesion, 4.1% were reported as benign with atypical cells (C3), 8.1% cases were suspicious for malignancy (C4), and 55.4% were positive for malignancy (C5). On histopathology examination, out of 24 cases which were reported as C2 lesions, 95.8% were benign and 4.1% turned out to be invasive ductal carcinoma. Of the cases that presented as C3 lesions, one was diagnosed as benign duct ectasia, one with ductal carcinoma in situ, and one with invasive ductal carcinoma on histopathological examination. The cases that were diagnosed as C4 lesions all turned out to be carcinoma on histopathology.  In this study, FNAC and histopathology diagnoses were strongly correlated [r 0.92, p <0.001]. Conclusion: Diagnosis of breast lump based on FNAC should be practiced as there is high correlation with histopathological finding. FNAC should be used as a routine...

Metrics

Metrics Loading ...

Author Biography

Adnan Khan, Rehman Medical College, Peshawar, Pakistan.

Adnan is a 4th year medical student of a five year program (MBBS) at Rehman

Medical College, Peshawar,Pakistan.

References

1. Coleman MP, Quaresma M, berrino F, lutz J-M, Angelis De, capocaccia R. Cancer survival in five continents: a worldwide population-based study (CONCORD). Lancet Oncol, 2008 Aug;9(8),730–56.
2. Aslam S, Hameed S, Afzal T, Hussain A, Zafar H, Naz M, et al. Correlation of FNAC and Histological diagnosis in the evaluation of breast lumps. JUMDC. 2012 Jul-Dec;3(2):1-7.
3. Khemka A, Chakrabarti N, Shah S, Patel V. Palpable Breast Lumps: Fi¬ne-Needle Aspiration Cytology versus Histopathology: a Correlation of Diag¬nostic Accuracy. Internet Journal of Surgery. 2009;18(1).
4. Qureshi H, Amanullah A, Khan KM, Deeba F. Efficacy of fine needle aspira¬tion cytology in the diagnosis of breast lumps. JPMI. 2011;21(4):301-4.
5. Yong W, Chia K, Poh W, Wong C. A comparison of trucut biopsy with fine needle aspiration cytology in the diagnosis of breast cancer. Singapore Med J. 1999 Sep;40(9):587-9.
6. Rahman S, Ali M, Khalili Y, Ali A, Lal A. Role of fine needle asporation cyto¬logy in evaluating the breast lumps. Gomal J Med Sci. 2011 Jan-Jun;9(1):59-61.
7. Baak J.P.A. The relative prognostic significance of nucleolar morphology in invasive ductal breast cancer. Histopathology. 1985 Apr;9(4):437-44.
8. Boerner S, Sneige N. Specimen adequacy and false-negative diagnosis rate in fine-needle aspirates of palpable breast masses. Cancer. 1998 Dec 25;84(6):344-8..
9. Feichter GE, Haberthür F, Gobat S, Dalquen P. Breast cytology. Acta cytolo¬gica. 1997 Mar-Apr;41(2):327-32.
10. Bajwa R, Zulfiqar T. Association of fine needle aspiration cytology with tumor size in palpable breast lesions. Biomedica. 2010 Jul-Dec;26:124-9.
11. Wilkinson EJ, Bland KI. Techniques and results of aspiration cytology for diagnosis of benign and malignant diseases of the breast. Surg Clin North Am. 1990 Aug;70(4):801-13.
12. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observa¬tional studies. PLoS Med. 2007 Oct 16;4(10):e296.
13. IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.
14. Sohail S, Alam SN. Breast cancer in pakistan-awareness and early de¬tection. Journal of the College of Physicians and Surgeons--Pakistan: JJ Coll Physicians Surg Pak. 2007 Dec;17(12):711-2.
15. Nasuti JF, Gupta PK, Baloch ZW. Diagnostic value and cost-effectiveness of on-site evaluation of fine-needle aspiration specimens: review of 5,688 cases. Diagn Cytopathol. 2002 Jul;27(1):1-4.
16. Rupom TU, Choudhury T, Banu SG. Study of Fine Needle Aspiration Cyto¬logy of Breast Lump: Correlation of Cytologically Malignant Cases with Their Histological Findings. BSMMU J. 2011;4(2):60-64.
17. Waqar AJ, Zada N and Israr M. Comparison of FNAC and core needle biopsy for evaluating breast lumps. JCPSP. 2002; 12: 686-8.
18. Gukas I, Nwana E, Ihezue C, Momoh J, Obekpa P. Tru-cut biopsy of palpa¬ble breast lesions: a practical option for pre-operative diagnosis in develo¬ping countries. Cent Afr J Med. 2000 May;46(5):127-30.
19. Tiryaki T, Senel E, Hucumenoglu S, Cakir BC, Kibar AE. Breast fibroadeno¬ma in female adolescents. Saudi Med J. 2007 Jan;28(1):137-8.
20. Guray M, Sahin AA. Benign breast diseases: classification, diagnosis, and management. Oncologist. 2006 May;11(5):435-49.
21. Bukhari MH, Arshad M, Jamal S, Niazi S, Bashir S, Bakhshi IM. Use of fine-needle aspiration in the evaluation of breast lumps. Patholog Res Int. 2011;2011:689521.
22. Bakhos R, Selvaggi SM, DeJong S, Gordon DL, Pitale SU, Herrmann M, Wojcik EM. Fine-needle aspiration of the thyroid: rate and causes of cytohistopathologic discordance. Diagn Cytopathol. 2000 Oct;23(4):233-7.
23. Bagga PK, Mahajan NC. Fine needle aspiration cytology of thyroid swellings: how useful and accurate is it?. Indian J Cancer. 2010 Oct-Dec;47(4):437-42.

Downloads

Published

2014-06-28

How to Cite

Khan, A., Jamali, R., Jan, M., & Tasneem, M. (2014). Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps. International Journal of Medical Students, 2(2), 40–43. https://doi.org/10.5195/ijms.2014.78

Issue

Vol. 2 No. 2 (2014)

Section

Original Article

Categories

License

  1. The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
  2. Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
  3. The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
    1. Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site; with the understanding that the above condition can be waived with permission from the Author and that where the Work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
    2. The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgment of its initial publication in this journal.
    3. Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
    4. Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
    5. The Author represents and warrants that:
      1. the Work is the Author’s original work;
      2. the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
      3. the Work is not pending review or under consideration by another publisher;
      4. the Work has not previously been published;
      5. the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
      6. the Work contains no libel, invasion of privacy, or other unlawful matter.
    6. The Author agrees to indemnify and hold Publisher harmless from the Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.

Enforcement of copyright

The IJMS takes the protection of copyright very seriously.

If the IJMS discovers that you have used its copyright materials in contravention of the license above, the IJMS may bring legal proceedings against you seeking reparation and an injunction to stop you using those materials. You could also be ordered to pay legal costs.

If you become aware of any use of the IJMS' copyright materials that contravenes or may contravene the license above, please report this by email to contact@ijms.org

 

Infringing material

If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to contact@ijms.org

Most read articles by the same author(s)