Postoperative and Postpartum Onset of Chronic Parkinsonism: Four Case Reports
Keywords:Parkinsonian disorders, Postoperative period, Postpartum period, Parkinson's disease secondary, Anesthesia
Background: Certain environmental exposures have been linked to the development of parkinsonism. We report four cases in which the onset of chronic parkinsonism occurred immediately or soon after surgery or childbirth.
Results: Exposure to certain anesthetic agents in susceptible individuals or the physiological changes associated with surgery or childbirth may have contributed to or precipitated the development of parkinsonism.
Conclusion: Clinicians should be aware that postoperative or postpartum settings are potential precipitants of chronic parkinsonism. More research is needed to clarify contributing factors.
2. Janis KM. Acute rigidity with small intravenous dose of Innovar. A case report. Anesth Analg. 1972;51(3):375-6.
3. Goldberg M, Ishak S, Garcia C, McKenna J. Postoperative rigidity following sufentanil administration. Anesthesiology. 1985;63(2):199-201.
4. Klausner JM, Caspi J, Lelcuk S, Khazam A, Marin G, Hechtman HB, et al. De¬layed muscular rigidity and respiratory depression following fentanyl anes¬thesia. Arch Surg. 1988;123(1):66-7.
5. Easdown LJ, Tessler MJ, Minuk J. Upper airway involvement in Parkin¬son's disease resulting in postoperative respiratory failure. Can J Anaesth. 1995;42(4):344-7.
6. el-Maghrabi EA, Eckenhoff RG. Inhibition of dopamine transport in rat bra¬in synaptosomes by volatile anesthetics. Anesthesiology. 1993;78(4):750-6.
7. Mantz J, Varlet C, Lecharny JB, Henzel D, Lenot P, Desmonts JM. Effects of volatile anesthetics, thiopental, and ketamine on spontaneous and depola¬rization-evoked dopamine release from striatal synaptosomes in the rat. Anesthesiology. 1994;80(2):352-63.
8. Nicholson G, Pereira AC, Hall GM. Parkinson's disease and anaesthe¬sia. Br J Anaesth. 2002;89(6):904-16.
9. Demirkiran M, Aslan K, Bicakci S, Bozdemir H, Ozeren A. Transient parkinsonism: induced by progesterone or pregnancy? Mov Disord. 2004;19(11):1382-4.
10. Kranick SM, Mowry EM, Colcher A, Horn S, Golbe LI. Movement disorders and pregnancy: a review of the literature. Mov Disord. 2010;25(6):665-71.
11. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, et al. The common inhalational anesthetic sevoflurane induces apop¬tosis and increases beta-amyloid protein levels. Arch Neurol. 2009;66(5):620-31.
12. Chen WH, Lin HS, Kao YF, Lan MY, Liu JS. Postoperative parkin¬sonism and lupus anticoagulant: a model of autoantibody-mediated neurotoxicity in stress. Brain Inj. 2007;21(5):539-43.
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