Associations Between Physical Activity and Age-Related Anti-Mullerian Hormone Decline: Insights from All of Us Research Program

Authors

  • Paige Coyne PhD Departamento de Ciencias de la Salud Pública, Henry Ford Health; Henry Ford Health + Michigan State University Health Sciences; Departamento de Epidemiología y Bioestadística, College of Human Medicine, Michigan State University, USA
  • Robert Leone MD Departamento de Ciencias de la Salud Pública, Henry Ford Health; Facultad de Medicina, Wayne State University, USA.ry Ford Health + Michigan State University Health Sciences, USA
  • Ze Meng MS Departamento de Ciencias de la Salud Pública, Henry Ford Health, USA.epartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, USA
  • Richard E Leach MD, FACOG, FACSHenry Ford Health + Michigan State University Health Sciences; Departamento de Obstetricia, Ginecología y Biología Reproductiva, College of Human Medicine, Michigan State University; Departamento de Obstetricia, Ginecología y Servicios de Salud de la Mujer, Henry Ford Health, USA
  • Sara santarossa PhD Departamento de Ciencias de la Salud Pública, Henry Ford Health; Henry Ford Health + Michigan State University Health Sciences; Departamento de Obstetricia, Ginecología y Biología Reproductiva, College of Human Medicine, Michigan State University, USA

DOI:

https://doi.org/10.5195/ijms.2023.3083

Keywords:

Fitbit, fertility, fecundity, women, exercise

Abstract

Background: Anti-mullerian hormone (AMH) is used to measure ovarian reserve and female fertility levels. Physical activity is thought to influence fertility and warrants further investigation, especially using objective measures. Methods: Using the All of Us Research Program dataset, the relationship between normal age-based decline in AMH and levels of physical activity were examined. Inclusion criteria were: ≥ 1 AMH test in electronic health record, AMH level < 7 ng/ml, and ≥ 30 days of valid Fitbit data within 1 year prior to AMH test. Final dataset included 24 participants. Results: Generalized linear regression models were fitted between log transformed AMH level and daily average activity intensity minutes (sedentary, lightly active, fairly active and very active) and daily step counts. Daily average of “very active” minutes showed a trend towards a positive effect on preventing the decline of AMH levels (B = 0.02 (95% CI 0-0.04), p = 0.136), though results were not statistically significant. Conclusion: Despite its small sample size, this study is one of the first to report a positive correlation, approaching significance, between objectively measured physical activity and preserving AMH, suggesting that daily high intensity physical activity may extend ovarian reserve. Further studies, with large, diverse samples are needed to provide clearer numbers for optimal engagement in physical activity and AMH level for fertility.

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References

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The image presents a table summarizing the cohort characteristics, showing mean values and standard deviations for key variables. The reported measures include AMH levels of 2.30 ng/ml (SD 2.05), an average of 808.14 sedentary minutes per day (SD 180.85), 12.10 minutes of moderate to fairly active activity per day (SD 8.18), and a daily step count of 6,897.51 (SD 2,578.99).

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Published

2025-07-28 — Updated on 2025-09-17

How to Cite

Coyne, P., Leone, R., Meng, Z., Leach, R. E., & santarossa, S. (2025). Associations Between Physical Activity and Age-Related Anti-Mullerian Hormone Decline: Insights from All of Us Research Program. International Journal of Medical Students, 303–307. https://doi.org/10.5195/ijms.2023.3083

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Forthcoming

Section

Short Communication

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