Is it all in our Heads? The Role of CaMKII in Neurogenic Hypertension

Authors

  • Nathaniel Edward Hayward School of Medicine and Health, University College Cork, Cork, Ireland.
  • Paul MacDaragh Ryan School of Medicine and Health, University College Cork, Cork, Ireland.
  • Ryan Taylor Sless School of Medicine and Health, University College Cork, Cork, Ireland.

DOI:

https://doi.org/10.5195/ijms.2018.272

Keywords:

CaMKII, Neurogenic Hypertension

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Author Biographies

Nathaniel Edward Hayward, School of Medicine and Health, University College Cork, Cork, Ireland.

Nathaniel Edward Hayward, M.Sc. is a student at the School of Medicine and Health, University College Cork, Cork, Ireland.

Paul MacDaragh Ryan, School of Medicine and Health, University College Cork, Cork, Ireland.

Paul M. Ryan is an early stage scientist holding a PhD on the gut microbiome and host cardiometabolic function interaction. Currently studying Medicine (MB, BCh, BAO) in University College Cork, and continuing research projects within the Centre for Research in Vascular Biology, UCC. PhD programme was part of the FP7-funded FibeBiotics consortium and was associated with the world-leading APC Microbiome Institute, UCC.

Ryan Taylor Sless, School of Medicine and Health, University College Cork, Cork, Ireland.

Ryan T. Sless, M.Sc. is a student at the School of Medicine and Health, University College Cork, Cork, Ireland.

References

Li DP, Zhou JJ, Zhang J, Pan HL. CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. J Neurosci. 2017 Nov 1;37(44):10690-9.

Mann SJ. Neurogenic essential hypertension revisited: the case for increased clinical and research attention. Am J Hypertens. 2003 Oct;16(10):881-8.

Stocker SD, Kinsman BJ, Sved AF. Recent Advances in Neurogenic Hypertension: Dietary Salt, Obesity, and Inflammation. Hypertension. 2017 Jul 24. pii: hypertensionaha.117.08936.

Li DP, Pan HL. Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertension. J Pharmacol Exp Ther. 2007 Feb;320(2):615-26.

Ye ZY, Li DP, Li L, Pan HL. Protein Kinase CK2 Increases Glutamatergic Input in the Hypothalamus and Sympathetic Vasomotor Tone in Hypertension. J Neurosci. 2011 Jun 1;31(22):8271-9.

Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. mGluR5 Upregulation Increases Excitability of Hypothalamic Presympathetic Neurons through NMDA Receptor Trafficking in Spontaneously Hypertensive Rats. J Neurosci. 2014 Mar 19;34(12):4309-17.

Schwarzl M, Hamdani N, Seiler S, Alogna A, Manninger M, Reilly S, et al. A porcine model of hypertensive cardiomyopathy: implications for heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1407-18.

Winklewski PJ, Radkowski M, Wszedybyl-Winklewska M, Demkow U. Brain inflammation and hypertension: the chicken or the egg? J Neuroinflammation. 2015 May 3;12:85.

Materson BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kochar MS, et al. Single-Drug Therapy for Hypertension in Men. A Comparison of Six Antihypertensive Agents with Placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. N Engl J Med. 1993 Apr 1;328(13):914-21.

Dudenbostel T, Siddiqui M, Gharpure N, Calhoun DA. Refractory versus resistant hypertension: Novel distinctive phenotypes. J Nat Sci. 2017 Sep;3(9):e430.

Published

2018-11-07

How to Cite

Hayward, N. E., Ryan, P. M., & Sless, R. T. (2018). Is it all in our Heads? The Role of CaMKII in Neurogenic Hypertension. International Journal of Medical Students, 6(3), 129–131. https://doi.org/10.5195/ijms.2018.272

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Letter to the Editor

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