Association of Reproductive Parameters with Dermatoglyphics in Breast Cancer Patients, Healthy and High-Risk Individuals
Keywords:Breast Neoplasm, Dermatoglyphics, Menarche, Menopause, Parity
Breast cancer has a wide array of risk factors, and its confounding reproductive aetiologies have been paramount in defining the predictive ability of the disease. Similarly, a strong link between qualitative dermatoglyphic patterns and predisposition to breast cancer has been well documented through genetic linkage. Therefore, this study aimed to discern the affiliation between the aforementioned risk factors of breast cancer.
The study was carried out in 3 groups of 90 age-matched individuals of - breast cancer patients, high-risk individuals and healthy individuals. A detailed reproductive history was taken including factors such as age at menarche, menstrual regularity, age at menopause (if attained), breastfeeding, obstetric parameters and age at first live birth. Qualitative dermatoglyphics were procured through the standardised ink and paper method to get a remarkable rolled fingerprint. The variations in gynaecological and obstetric parameters and qualitative dermatoglyphic patterns were studied and their significance was computed using the chi-square test on InStat software where p values < 0.05 were considered significant with a 95% confidence interval.
Highly significant values (p<0.0001) were found in all gynaecological and obstetric parameters where a higher frequency of whorls in breast cancer patients, arches in high-risk individuals and an equivalent frequency of arches and whorls were predisposed to healthy individuals.
Although this study might have identified certain predominating patterns with higher frequency, the consistency might vary from place to place due to differing dermatoglyphics according to ethnicity.
A small number of patients receiving chemotherapy experienced - chemotherapy-induced adermatoglyphia - where the loss of fingerprints or very faint fingerprints was difficult to perceive. These patients were not included in the study to ensure maximum efficacy in interpreting the dermatoglyphics.
Previous attempts failed to link dermatoglyphic indices and reproductive parameters, this study found a significant correlation between the variables in the three distinct groups. Most breast cancer patients are diagnosed late with a majority presenting to doctors in advanced stages where survival rates are marginal, so by this method, we can get a simple, practical, non-invasive and easily affordable screening technique for the above risk factors. This technique could also be employed for non-symptomatic women who might have a positive family history of breast cancer as a part of risk assessment for early diagnosis and treatment. Therefore, paving way for further research into the prognostic abilities of gynaecological parameters through qualitative dermatoglyphic indices.
- 2023-02-20 (2)
- 2022-12-31 (1)
How to Cite
Copyright (c) 2022 Rahul Rangan, Swapna A. Shedge, Satish V. Kakade
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
- Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
- The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
- Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site; with the understanding that the above condition can be waived with permission from the Author and that where the Work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
- The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
- Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
- The Author represents and warrants that:
- the Work is the Author’s original work;
- the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
- the Work is not pending review or under consideration by another publisher;
- the Work has not previously been published;
- the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
- the Work contains no libel, invasion of privacy, or other unlawful matter.
- The Author agrees to indemnify and hold Publisher harmless from the Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.
Enforcement of copyright
The IJMS takes the protection of copyright very seriously.
If the IJMS discovers that you have used its copyright materials in contravention of the license above, the IJMS may bring legal proceedings against you seeking reparation and an injunction to stop you using those materials. You could also be ordered to pay legal costs.
If you become aware of any use of the IJMS' copyright materials that contravenes or may contravene the license above, please report this by email to email@example.com
If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to firstname.lastname@example.org